Fyodor A. Kondrashov is at the Center for Population Biology, Section of Evolution and Ecology, University of California at Davis, Davis, 95616, USA. kondrashov@ucdavis.edu
Negative trade-offs are thought to be a pervasive phenomenon and to inhibit evolution at all levels. New evidence shows that at the molecular level, there may be no trade-offs preventing the emergence of an enzyme with multiple functions.
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