Thomas G. Graeber is in the Crump Institute for Molecular Imaging and the Department of Molecular and Medical Pharmacology, and Charles L. Sawyers is in the Howard Hughes Medical Institute, and the Departments of Medicine, Molecular and Medical Pharmacology, and Urology at the David Geffen School of Medicine, University of California, Los Angeles, California, 90095, USA. tgraeber@mednet.ucla.edu, csawyers@mednet.ucla.edu
Modeling of human cancer in genetically engineered mice and genome-wide measurements of mRNA expression have now been combined to accelerate the search for new molecularly targeted therapies against cancer. Looking forward, we propose a community-wide systematic effort to model and characterize an array of different cancer-related aberrant signaling pathways in several mouse models of cancer.
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