John Schimenti is in the Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA. jcs92@cornell.edu
The XY chromosome pair in mammalian males is sequestered into a transcriptionally dormant chromatin domain before the first meiotic division. New work shows that all chromosomes can suffer the same fate if they don't pair during meiosis, and that this may be part of a surveillance mechanism to protect against aneuploid gametes.
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