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Brief Communication
Nature Genetics  36, 952 - 954 (2004)
Published online: 22 August 2004; | doi:10.1038/ng1417

Genomic segmental polymorphisms in inbred mouse strains

Jiangzhen Li1, 6, Tao Jiang1, 6, Jian-Hua Mao2, Allan Balmain2, Leif Peterson1, 3, Charles Harris4, Pulivarthi H Rao4, Paul Havlak1, 5, Richard Gibbs1, 5 & Wei-Wen Cai1

1  Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

2  Cancer Research Institute, University of California at San Francisco, 2340 Sutter Street, San Francisco, California 94143, USA.

3  Department of Medicine, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

4  Department of Pediatrics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

5  Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

6  These authors contributed equally to this work.

Correspondence should be addressed to Wei-Wen Cai wcai@bcm.tmc.edu
By analyzing genomic copy-number differences using high-resolution mouse whole-genome BAC arrays, we uncover substantial differences in regional DNA content between inbred strains of mice. The identification of these apparently common segmental polymorphisms suggests that these differences can contribute to genetic variability and pathologic susceptibility.


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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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