Nature Genetics
36, 906 - 912 (2004)
Published online: 25 July 2004; | doi:10.1038/ng1396
Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiationXinzhu Deng, E Randal Hofmann, Alberto Villanueva, Oliver Hobert, Paola Capodieci, Darren R Veach, Xianglei Yin, Luis Campodonico, Athanasios Glekas, Carlos Cordon-Cardo, Bayard Clarkson, William G Bornmann, Zvi Fuks, Michael O Hengartner
& Richard KolesnickSupplementary Fig. 1 (pdf 52K)
abl-1 encodes five different transcripts generated by cis- and or trans-splicing mechanisms that yield different NH2-termini. Supplementary Fig. 2 (pdf 362K)
36 hours post 120 Gy irradiation, germ cell apoptosis in wild-type worms was detected with SYTO as viewed by Nomarski DIC optics and fluorescence imaging. Supplementary Fig. 3 (pdf 35K)
The interaction of ABL-1 and human p53 in HEK293 cells after ionizing radiation. Supplementary Fig. 4 (pdf 84K)
The schematic diagram of the interaction of PD166326 with the kinase domains of human Abl and C. elegans ABL-1. Supplementary Table 1 (pdf 4K)
Germ cell corpses are removed at a normal rate in abl-1(ok171). Supplementary Table 2 (pdf 4K)
Programmed cell death genes are required for radiation-induced germ cell apoptosis in abl-1(ok171). Supplementary Methods (pdf 30K)
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