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Letter

Nature Genetics 36, 906–912 (1 August 2004) | doi:10.1038/ng1396

Caenorhabditis elegans ABL-1 antagonizes p53-mediated germline apoptosis after ionizing irradiation

Xinzhu Deng , E Randal Hofmann , Alberto Villanueva , Oliver Hobert , Paola Capodieci , Darren R Veach , Xianglei Yin , Luis Campodonico , Athanasios Glekas , Carlos Cordon-Cardo , Bayard Clarkson , William G Bornmann , Zvi Fuks , Michael O Hengartner & Richard Kolesnick

c-Abl, a conserved nonreceptor tyrosine kinase, integrates genotoxic stress responses, acting as a transducer of both pro- and antiapoptotic effector pathways. Nuclear c-Abl seems to interact with the p53 homolog p73 to elicit apoptosis.