Oscar Fernandez-Capetillo and André Nussenzweig are in the Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. andre_nussenzweig@nih.gov
The acquisition of an abnormal number of chromosomes is a hallmark of many human cancers. A new study indicates that unequal segregation of genetic material to daughter cells during cell division can also lead to premature senescence and accelerated onset of a variety of aging phenotypes.
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