Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Letter
Nature Genetics 36, 618–623 (1 June 2004) | doi:10.1038/ng1360
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex
&
Abstract
Telomere length in humans is partly controlled by a feedback mechanism in which telomere elongation by telomerase is limited by the accumulation of the TRF1 complex at chromosome ends. TRF1 itself can be inhibited by the poly(ADP-ribose) polymerase (PARP) activity of its interacting partner tankyrase 1, which abolishes its DNA binding activity in vitro and removes the TRF1 complex from telomeres in vivo.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
