Carson C. Thoreen and David M. Sabatini are at the Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, USA. Sabatini@wi.mit.edu
A new study identifies a protective role for cellular aggregates in Huntington disease by showing that aggregates promote the clearance of mutant protein by activating autophagy through the inhibition of mTOR. This challenges the common view that they are possibly innocuous but probably harmful to the host cell.
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