Derek L. Stirewalt is in the Clinical Research Division, Program in Genetics and Genomics, Fred Hutchison Cancer Research Center, Seattle, Washington, USA. dstirewa@fhcrc.org
The transcription factor PU.1 has an essential role in hematopoiesis. New evidence shows that reducing PU.1 expression to 20% of wild-type levels results in an aggressive form of acute myeloid leukemia.
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