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Letter
Nature Genetics 36, 471–475 (1 May 2004) | doi:10.1038/ng1339
Functional variants of OCTN cation transporter genes are associated with Crohn disease
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Abstract
Crohn disease is a chronic, inflammatory disease of the gastrointestinal tract. A locus of |[sim]|250 kb at 5q31 (IBD5) was previously associated with susceptibility to Crohn disease, as indicated by increased prevalence of a risk haplotype of 11 single-nucleotide polymorphisms among individuals with Crohn disease, but the pathogenic lesion in the region has not yet been identified.
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