Mark Schlissel is in the Department of Molecular and Cell Biology at University of California, Berkeley, 439 LSA, Berkeley, California, USA. mss@uclink4.berkeley.edu
Specific post-translational histone modifications correlate with distinct patterns of gene activity. A new study of the mouse Dntt promoter shows that changes in gene activity are associated with local changes in histone modification that then spread outward in both directions, locking in the altered pattern of transcription.
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