Sally A. Camper is in the Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan 48109-0638, USA. scamper@umich.edu
Humans with mutations in SOX3 have panhypopituitarism, but the developmental mechanisms underlying this defect are unknown. Conditional disruption of Sox3 in mice now suggests that anterior pituitary development depends on Sox3 expression in the overlying neural ectoderm, which establishes midline structures and regulates production of inductive BMP and FGF signals.
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