Endre Máthé is at Cancer Research UK Cell Cycle Genetics Group, Department of Genetics, University of Cambridge, Downing Street, Cambridge, CB2 3EH, UK. em247@mole.bio.cam.ac.uk
The tumor suppressor gene RASSF1 contributes to the spatiotemporal regulation of mitosis through a new mechanism. By interacting with Cdc20, its protein product RASSF1A inhibits the anaphase-promoting complex and prevents degradation of cyclin A and cyclin B until the spindle checkpoint becomes fully operational.
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