Nature Genetics
36, 1255 - 1257 (2004)
Published online: 31 October 2004; | doi:10.1038/ng1469
There is a Corrigendum (January 2005) associated with this Brief Communication.
Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticityMichael Hiller1, 4, Klaus Huse2, 4, Karol Szafranski2, Niels Jahn2, Jochen Hampe3, Stefan Schreiber3, Rolf Backofen1
& Matthias Platzer21
Institute of Computer Science, Friedrich-Schiller-University Jena, Chair for Bioinformatics, Ernst-Abbe-Platz 2, 07743
Jena, Germany. 2
Genome Analysis, Institute of Molecular Biotechnology, Beutenbergstr. 11, 07745
Jena, Germany. 3
Institute for Clinical Molecular Biology, Christian-Albrechts-University Kiel, Schittenhelmstr. 12, 24105
Kiel, Germany. 4
These authors contributed equally to this work.
Correspondence should be addressed to Matthias Platzer mplatzer@imb-jena.deSplice acceptors with the genomic NAGNAG motif may cause NAG insertion-deletions in transcripts, occur in 30% of human genes and are functional in at least 5% of human genes. We found five significant biases indicating that their distribution is nonrandom and that they are evolutionarily conserved and tissue-specific. Because of their subtle effects on mRNA and protein structures, these splice acceptors are often overlooked or underestimated, but they may have a great impact on biology and disease.
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated.
|
