Katherine A. Siminovitch is at Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada. ksimin@mshri.on.ca
Protein tyrosine phosphatases (PTPs) have diverse roles as negative regulators of stimulatory signaling cascades and are widely recognized as key to maintaining immune cellular homeostasis. Recent data implicating the PTP Lyp in susceptibility to four autoimmune diseases attests to the biological importance of PTP immune regulatory roles and to the etiologic relatedness of different autoimmune conditions.
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