R. Kelly Dawe is in the Department of Plant Biology and Department of Genetics, University of Georgia, Athens, Georgia 30602, USA. kelly@plantbio.uga.edu
Transcriptional silencing in fission yeast requires several core components of the RNA interference machinery. A new study suggests that the recently discovered RNA-induced initiation of transcriptional gene silencing complex binds stably to silent chromatin, where it recruits short interfering RNAs and destroys nascent RNA molecules in cis.
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