Nature Genetics
36, 1117 - 1121 (2004)
Published online: 19 September 2004; | doi:10.1038/ng1430
BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt− -catenin signalingXi C He, Jiwang Zhang, Wei-Gang Tong, Ossama Tawfik, Jason Ross, David H Scoville, Qiang Tian, Xin Zeng, Xi He, Leanne M Wiedemann, Yuji Mishina
& Linheng LiSupplementary Fig. 1 (pdf 64K)
Western blot analysis to measure the protein levels of Pan-PTEN, P-PTEN, Pan-Akt, Akt-S473, and subcellular localization of  -catenin in intestines with different ex vivo treatment. Supplementary Fig. 2 (pdf 64K)
Illustration of the regulatory roles of the BMP signal and Wnt signaling mediated by the PTEN-PI3K pathway in regulation of stem cell self-renewal and transition between quiescent and activated states. Supplementary Methods (pdf 32K)
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