Access

Letter

Nature Genetics 36, 1079–1083 (1 October 2004) | doi:10.1038/ng1421

MicroRNA-responsive 'sensor' transgenes uncover Hox-like and other developmentally regulated patterns of vertebrate microRNA expression

Jennifer H Mansfield , Brian D Harfe , Robert Nissen , John Obenauer , Jalagani Srineel , Aadel Chaudhuri , Raphael Farzan-Kashani , Michael Zuker , Amy E Pasquinelli , Gary Ruvkun , Phillip A Sharp , Clifford J Tabin & Michael T McManus

MicroRNAs (miRNAs) are a class of short (|[sim]|22-nt) noncoding RNA molecules that downregulate expression of their mRNA targets. Since their discovery as regulators of developmental timing in Caenorhabditis elegans, hundreds of miRNAs have been identified in both animals and plants.