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Volume 36 Issue 10, October 2004

Cover: DNA Double Helix Tularosa Pot by Lee Brotherton www.trailsidegalleries.com

Volume 36 Issue 10

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Editorial

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Correspondence

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Book Review

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News & Views

  • MicroRNAs are important in the development of worms, flies and plants. A new study shows how the temporal and spatial expression patterns of such RNAs can be determined in mouse embryos, providing insights into the emerging role of microRNAs in Hox gene regulation.

    • John Cobb
    • Denis Duboule
    News & Views

  • Many genes and genetic mechanisms contributed to the evolution of humans from a common primate ancestor. Emergence of the ape brain was apparently facilitated by a retrotransposed gene duplicate that acquired brain-specific expression and functions affecting the neurotransmitter glutamate.

    • Ajit Varki
    News & Views

  • A new study shows that poly(ADP-ribosyl)ation of CTCF regulates its activity as a transcriptional insulator without altering its DNA binding properties. This mechanism provides cells with the flexibility to regulate gene expression without altering fundamental epigenetic programs.

    • Sangkyun Jeong
    • Karl Pfeifer
    News & Views

  • Studies of inherited cancer syndromes have implicated numerous signaling pathways in colorectal carcinogenesis, but the relationship between these signaling pathways remains poorly understood. Now, a new mouse model of juvenile polyposis syndrome identifies a molecular mechanism for clonal epithelial cell expansion and links several pathways with an established role in polyposis.

    • Gijs R van den Brink
    News & Views
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Review Article

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Brief Communication

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Article

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Letter

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Corrigendum

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