Sangkyun Jeong and Karl Pfeifer are in the Laboratory of Mammalian Genes and Development, Building 6B−206, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA. pfeiferk@mail.nih.gov
A new study shows that poly(ADP-ribosyl)ation of CTCF regulates its activity as a transcriptional insulator without altering its DNA binding properties. This mechanism provides cells with the flexibility to regulate gene expression without altering fundamental epigenetic programs.
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