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Journal home Advance online publication Current issue Archive Press releases Free Association (blog) Supplements Focuses Guide to authors Online submission For referees Free online issue Contact the journal Subscribe Advertising work@npg Reprints and permissions About this site For librarians   NPG Resources Nature Nature Biotechnology Nature Cell Biology Nature Medicine Nature Methods Nature Reviews Cancer Nature Reviews Genetics Nature Reviews Molecular Cell Biology news@nature.com Nature Conferences RNAi Gateway NPG Subject areas Biotechnology Cancer Chemistry Clinical Medicine Dentistry Development Drug Discovery Earth Sciences Evolution & Ecology Genetics Immunology Materials Science Medical Research Microbiology Molecular Cell Biology Neuroscience Pharmacology Physics Browse all publications ISSUE  Previous | Next  January 2004, Volume 36 No 1 Editorial Correspondence Book Review News and Views Review Brief Communication Articles Letters Errata About the cover Editorial  Top Chance is a necessity p1 doi:10.1038/ng0104-1 Full text | PDF (52K) Correspondence  Top A call for accurate phenotype definition in the study of complex disorders p3 Benoît Funalot, Olivier Varenne & Jean-Louis Mas doi:10.1038/ng0104-3a Full text | PDF (71K) Reply to "A call for accurate phenotype definition in the study of complex disorders" pp3 - 4 Jeffrey R Gulcher, Solveig Gretarsdottir, Augustine Kong & Kari Stefansson doi:10.1038/ng0104-3b Full text | PDF (78K) Book Review  Top A giant of genetics p5 Reviewed by: Gunther S Stent doi:10.1038/ng0104-5 Full text | PDF (104K) News and Views  Top Conquering the complexity of p53 pp7 - 8 Laura D Attardi & Ronald A DePinho doi:10.1038/ng0104-7 Abstract | Full text | PDF (270K) See also: Letter by Liu et al. White meat or dark? pp8 - 10 Ava E Brent & Clifford J Tabin doi:10.1038/ng0104-8 Abstract | Full text | PDF (1,177K) See also: Letter by Baxendale et al. Two Pax are better than one pp10 - 11 Richard S Mann doi:10.1038/ng0104-10 Abstract | Full text | PDF (107K) See also: Article by Dominguez et al. Marking Xs, together and separately pp12 - 13 Mary Ann Handel doi:10.1038/ng0104-12 Abstract | Full text | PDF (261K) See also: Letter by Bean et al. Diverse powerhouses pp13 - 14 David R Thorburn doi:10.1038/ng0104-13 Abstract | Full text | PDF (227K) Touching base p15 doi:10.1038/ng0104-15 Full text | PDF (175K) Research notes p17 doi:10.1038/ng0104-17 Full text | PDF (96K) Review  Top The four Rs of RNA-directed evolution pp19 - 25 Alan Herbert Published online: 30 December 2003 | doi:10.1038/ng1275 Abstract | Full text | PDF (190K) Brief Communication  Top Reductive evolution suggested from the complete genome sequence of a plant-pathogenic phytoplasma pp27 - 29 Kenro Oshima, Shigeyuki Kakizawa, Hisashi Nishigawa, Hee-Young Jung, Wei Wei, Shiho Suzuki, Ryo Arashida, Daisuke Nakata, Shin-ichi Miyata, Masashi Ugaki & Shigetou Namba Published online: 07 December 2003 | doi:10.1038/ng1277 Abstract | Full text | PDF (414K)  | Supplementary Information Articles  Top Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila melanogaster pp31 - 39 Maria Dominguez, Dolors Ferres-Marco, Francisco J Gutierrez-Aviño, Stephan A Speicher & Monica Beneyto Published online: 14 December 2003 | doi:10.1038/ng1281 Abstract | Full text | PDF (1,668K) See also: News and Views by Mann Complete sequencing and characterization of 21,243 full-length human cDNAs pp40 - 45 Toshio Ota, Yutaka Suzuki, Tetsuo Nishikawa, Tetsuji Otsuki, Tomoyasu Sugiyama, Ryotaro Irie, Ai Wakamatsu, Koji Hayashi, Hiroyuki Sato, Keiichi Nagai, Kouichi Kimura, Hiroshi Makita, Mitsuo Sekine, Masaya Obayashi, Tatsunari Nishi, Toshikazu Shibahara, Toshihiro Tanaka, Shizuko Ishii, Jun-ichi Yamamoto, Kaoru Saito, Yuri Kawai, Yuko Isono, Yoshitaka Nakamura, Kenji Nagahari, Katsuhiko Murakami, Tomohiro Yasuda, Takao Iwayanagi, Masako Wagatsuma, Akiko Shiratori, Hiroaki Sudo, Takehiko Hosoiri, Yoshiko Kaku, Hiroyo Kodaira, Hiroshi Kondo, Masanori Sugawara, Makiko Takahashi, Katsuhiro Kanda, Takahide Yokoi, Takako Furuya, Emiko Kikkawa, Yuhi Omura, Kumi Abe, Kumiko Kamihara, Naoko Katsuta, Kazuomi Sato, Machiko Tanikawa, Makoto Yamazaki, Ken Ninomiya, Tadashi Ishibashi, Hiromichi Yamashita, Katsuji Murakawa, Kiyoshi Fujimori, Hiroyuki Tanai, Manabu Kimata, Motoji Watanabe, Susumu Hiraoka, Yoshiyuki Chiba, Shinichi Ishida, Yukio Ono, Sumiyo Takiguchi, Susumu Watanabe, Makoto Yosida, Tomoko Hotuta, Junko Kusano, Keiichi Kanehori, Asako Takahashi-Fujii, Hiroto Hara, Tomo-o Tanase, Yoshiko Nomura, Sakae Togiya, Fukuyo Komai, Reiko Hara, Kazuha Takeuchi, Miho Arita, Nobuyuki Imose, Kaoru Musashino, Hisatsugu Yuuki, Atsushi Oshima, Naokazu Sasaki, Satoshi Aotsuka, Yoko Yoshikawa, Hiroshi Matsunawa, Tatsuo Ichihara, Namiko Shiohata, Sanae Sano, Shogo Moriya, Hiroko Momiyama, Noriko Satoh, Sachiko Takami, Yuko Terashima, Osamu Suzuki, Satoshi Nakagawa, Akihiro Senoh, Hiroshi Mizoguchi, Yoshihiro Goto, Fumio Shimizu, Hirokazu Wakebe, Haretsugu Hishigaki, Takeshi Watanabe, Akio Sugiyama, Makoto Takemoto, Bunsei Kawakami, Masaaki Yamazaki, Koji Watanabe, Ayako Kumagai, Shoko Itakura, Yasuhito Fukuzumi, Yoshifumi Fujimori, Megumi Komiyama, Hiroyuki Tashiro, Akira Tanigami, Tsutomu Fujiwara, Toshihide Ono, Katsue Yamada, Yuka Fujii, Kouichi Ozaki, Maasa Hirao, Yoshihiro Ohmori, Ayako Kawabata, Takeshi Hikiji, Naoko Kobatake, Hiromi Inagaki, Yasuko Ikema, Sachiko Okamoto, Rie Okitani, Takuma Kawakami, Saori Noguchi, Tomoko Itoh, Keiko Shigeta, Tadashi Senba, Kyoka Matsumura, Yoshie Nakajima, Takae Mizuno, Misato Morinaga, Masahide Sasaki, Takushi Togashi, Masaaki Oyama, Hiroko Hata, Manabu Watanabe, Takami Komatsu, Junko Mizushima-Sugano, Tadashi Satoh, Yuko Shirai, Yukiko Takahashi, Kiyomi Nakagawa, Koji Okumura, Takahiro Nagase, Nobuo Nomura, Hisashi Kikuchi, Yasuhiko Masuho, Riu Yamashita, Kenta Nakai, Tetsushi Yada, Yusuke Nakamura, Osamu Ohara, Takao Isogai & Sumio Sugano Published online: 21 December 2003 | doi:10.1038/ng1285 Abstract | Full text | PDF (262K)  | Supplementary Information RPA regulates telomerase action by providing Est1p access to chromosome ends pp46 - 54 Vera Schramke, Pierre Luciano, Vanessa Brevet, Sylvine Guillot, Yves Corda, Maria Pia Longhese, Eric Gilson & Vincent Géli Published online: 21 December 2003 | doi:10.1038/ng1284 Abstract | Full text | PDF (1,725K) Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53 pp55 - 62 Hiroshi Katayama, Kaori Sasai, Hidehiko Kawai, Zhi-Min Yuan, Jolanta Bondaruk, Fumio Suzuki, Satoshi Fujii, Ralph B Arlinghaus, Bogdan A Czerniak & Subrata Sen Published online: 14 December 2003 | doi:10.1038/ng1279 Abstract | Full text | PDF (2,335K)  | Supplementary Information Letters  Top Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice pp63 - 68 Geng Liu, John M Parant, Gene Lang, Patty Chau, Arturo Chavez-Reyes, Adel K El-Naggar, Asha Multani, Sandy Chang & Guillermina Lozano Published online: 21 December 2003 | doi:10.1038/ng1282 Abstract | Full text | PDF (1,547K) See also: News and Views by Attardi & DePinho Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex pp69 - 76 Volney L Sheen, Vijay S Ganesh, Meral Topcu, Guillaume Sebire, Adria Bodell, R Sean Hill, P Ellen Grant, Yin Yao Shugart, Jaime Imitola, Samia J Khoury, Renzo Guerrini & Christopher A Walsh Published online: 30 November 2003 | doi:10.1038/ng1276 Abstract | Full text | PDF (2,799K)  | Supplementary Information Mutations in HFE2 cause iron overload in chromosome 1q−linked juvenile hemochromatosis pp77 - 82 George Papanikolaou, Mark E Samuels, Erwin H Ludwig, Marcia L E MacDonald, Patrick L Franchini, Marie-Pierre Dubé, Lisa Andres, Julie MacFarlane, Nikos Sakellaropoulos, Marianna Politou, Elizabeta Nemeth, Jay Thompson, Jenni K Risler, Catherine Zaborowska, Ryan Babakaiff, Christopher C Radomski, Terry D Pape, Owen Davidas, John Christakis, Pierre Brissot, Gillian Lockitch, Tomas Ganz, Michael R Hayden & Y Paul Goldberg Published online: 30 November 2003 | doi:10.1038/ng1274 Abstract | Full text | PDF (1,714K) Conversion of biliary system to pancreatic tissue in Hes1-deficient mice pp83 - 87 Ryo Sumazaki, Nobuyoshi Shiojiri, Shigemi Isoyama, Masayuki Masu, Kazuko Keino-Masu, Mitsujiro Osawa, Hiromitsu Nakauchi, Ryoichiro Kageyama & Akira Matsui Published online: 14 December 2003 | doi:10.1038/ng1273 Abstract | Full text | PDF (1,617K) The B-cell maturation factor Blimp-1 specifies vertebrate slow-twitch muscle fiber identity in response to Hedgehog signaling pp88 - 93 Sarah Baxendale, Claire Davison, Claire Muxworthy, Christian Wolff, Philip W Ingham & Sudipto Roy Published online: 21 December 2003 | doi:10.1038/ng1280 Abstract | Full text | PDF (2,352K)  | Supplementary Information See also: News and Views by Brent & Tabin Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases pp94 - 99 Marta García-Cao, Roderick O'Sullivan, Antoine H F M Peters, Thomas Jenuwein & María A Blasco Published online: 14 December 2003 | doi:10.1038/ng1278 Abstract | Full text | PDF (1,901K)  | Supplementary Information Meiotic pairing and imprinted X chromatin assembly in Caenorhabditis elegans pp100 - 105 Christopher J Bean, Christine E Schaner & William G Kelly Published online: 21 December 2003 | doi:10.1038/ng1283 Abstract | Full text | PDF (1,001K) See also: News and Views by Handel Errata  Top Erratum: Chipping away at the chip bias: RNA degradation in microarray analysis p106 H Auer, S Lyianarachchi, D Newsom, M I Klisovic, G Marcucci & K Kornacker doi:10.1038/ng0104-106a Full text | PDF (41K) Erratum: Gene-culture coevolution between cattle milk protein genes and human lactase genes p106 A Beja-Pereira, G Luikart, P R England, D G Bradley, O C Jann, G Bertorelle, A T Chamberlain, T P Nunes, S Metodiev, N Ferrand & G Erhardt doi:10.1038/ng0104-106b Full text | PDF (41K)   Top   ADVERTISEMENT Register for table of contents e-alerts Recommend to your library Receive news feeds what is a news feed?  View table of contents PDF Open Innovation Challenges Methods of Modeling Adaptation in Populations Deadline: Dec 30 2009 Reward: $15,000 USD The analysis of adaptation with a population is a frequently encountered computational modeling scen... 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