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News and Views
Nature Genetics  36, 7 - 8 (2004)
doi:10.1038/ng0104-7

Conquering the complexity of p53

Laura D Attardi1 & Ronald A DePinho2

1  Laura D. Attardi is in the Departments of Radiation Oncology and Genetics, Stanford University School of Medicine, Stanford, California 94305, USA. attardi@stanford.edu

2  Ronald A. DePinho is in the Department of Medical Oncology, Dana-Farber Cancer Institute and the Departments of Medicine and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA. ron_depinho@dfci.harvard.edu

New evidence from a Trp53 'knock-in' mouse model suggests that p53-dependent cell cycle checkpoint control accompanied by maintenance of genome stability is important for keeping tumor growth in check.

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