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Letter

Nature Genetics 35, 372–376 (1 December 2003) | doi:10.1038/ng1271

WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion

Kristopher T Kahle , Frederick H Wilson , Qiang Leng , Maria D Lalioti , Anthony D O'Connell , Ke Dong , Alicia K Rapson , Gordon G MacGregor , Gerhard Giebisch , Steven C Hebert & Richard P Lifton

A key question in systems biology is how diverse physiologic processes are integrated to produce global homeostasis. Genetic analysis can contribute by identifying genes that perturb this integration.