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Letter
Nature Genetics 35, 357–362 (1 December 2003) | doi:10.1038/ng1260
Pyruvate kinase deficiency in mice protects against malaria
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Abstract
The global health impact of malaria is enormous, with an estimated 300–500 million clinical cases and 1 million annual deaths. In humans, initial susceptibility to infection with Plasmodium species, disease severity and ultimate outcome of malaria (self-healing or lethal) are under complex genetic control.
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