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Nature Genetics  35, 311 - 313 (2003)
Published online: 23 November 2003; | doi:10.1038/ng1263

Gene-culture coevolution between cattle milk protein genes and human lactase genes

Albano Beja-Pereira, Gordon Luikart, Phillip R England, Daniel G Bradley, Oliver C Jann, Giorgio Bertorelle, Andrew T Chamberlain, Telmo P Nunes, Stoitcho Metodiev, Nuno Ferrand & Georg Erhardt
 
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Figure 1. Geographic coincidence between milk gene diversity in cattle, lactose tolerance in humans and locations of Neolithic cattle farming sites in NCE.
(a) Geographic distribution of the 70 cattle breeds (blue dots) sampled across Europe and Turkey. (b) Synthetic map showing the first principal component resulting from the allele frequencies at the cattle genes. The dark orange color shows that the greatest milk gene uniqueness and allelic diversity occurs in cattle from NCE. (c) Geographic distribution of the lactase persistence allele in contemporary Europeans. The darker the orange color, the higher is the frequency of the lactase persistence allele. The dashed black line indicates the limits of the geographic distribution of early Neolithic cattle pastoralist (Funnel Beaker Culture) inferred from archaeological data15.

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