A molecular switch controlling renal sodium and potassium excretion
René J M Bindels
René Bindels is at the Department of Physiology, Nijmegen Centre for Molecular Life Sciences, University Medical Centre Nijmegen, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. r.bindels@ncmls.kun.nl
A new study shows that the kinase WNK4 is a molecular switch that regulates the trafficking of both a sodium-chloride cotransporter and a potassium channel in the kidney. This finding suggests a key role for WNK4 in ion homeostasis in health and disease.
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