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Letter

Nature Genetics 35, 270–276 (1 November 2003) | doi:10.1038/ng1257

Interaction of reelin signaling and Lis1 in brain development

Amir H Assadi , Guangcheng Zhang , Uwe Beffert , Robert S McNeil , Amy L Renfro , Sanyong Niu , Carlo C Quattrocchi , Barbara A Antalffy , Michael Sheldon , Dawna D Armstrong , Anthony Wynshaw-Boris , Joachim Herz , Gabriella D'Arcangelo & Gary D Clark

Loss-of-function mutations in RELN (encoding reelin) or PAFAH1B1 (encoding LIS1) cause lissencephaly, a human neuronal migration disorder. In the mouse, homozygous mutations in Reln result in the reeler phenotype, characterized by ataxia and disrupted cortical layers.