1
Chris Tyler-Smith is at The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SA, UK cts@sanger.ac.uk
2
Gil McVean is in the Department of Statistics, University of Oxford, Oxford, OX1 3TG, UK.
A deletion that removes 1.6 Mb of DNA and several genes from the Y chromosome increases its carriers' chance of infertility, yet is present in 2% of men. The Y chromosome can no longer be regarded as a neutral locus in evolutionary studies.
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