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News and Views
Nature Genetics  35, 201 - 202 (2003)
doi:10.1038/ng1103-201

The comings and goings of a Y polymorphism

Chris Tyler-Smith1 & Gil McVean2

1  Chris Tyler-Smith is at The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SA, UK cts@sanger.ac.uk

2  Gil McVean is in the Department of Statistics, University of Oxford, Oxford, OX1 3TG, UK.

A deletion that removes 1.6 Mb of DNA and several genes from the Y chromosome increases its carriers' chance of infertility, yet is present in approx2% of men. The Y chromosome can no longer be regarded as a neutral locus in evolutionary studies.

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NEWS AND VIEWS
The fragility of fertility
Nature Genetics News and Views (01 Nov 2001)

RESEARCH
Polymorphism for a 1.6-Mb deletion of the human Y chromosome persists through balance between recurrent mutation and haploid selection
Nature Genetics Letters (01 Nov 2003)
The AZFc region of the Y chromosome features massive palindromes and uniform recurrent deletions in infertile men
Nature Genetics Article (01 Nov 2001)
Human chromosome 15q11-q14 regions of rearrangements contain clusters of LCR15 duplicons
European Journal of Human Genetics Original Article (04 Mar 2002)
Apparent intrachromosomal exchange on the human Y chromosome explained by population history
European Journal of Human Genetics Original Article (01 Apr 2003)

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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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