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Letter
Nature Genetics 35, 176–179 (1 October 2003) | doi:10.1038/ng1242
Evolutionary conservation of motif constituents in the yeast protein interaction network
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Abstract
Understanding why some cellular components are conserved across species but others evolve rapidly is a key question of modern biology. Here we show that in Saccharomyces cerevisiae, proteins organized in cohesive patterns of interactions are conserved to a substantially higher degree than those that do not participate in such motifs.
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