Journal home
Advance online publication
Current issue
Archive
Press releases
Free Association (blog)
Supplements
Focuses
Guide to authors
Online submissionOnline submission
For referees
Free online issue
Contact the journal
Subscribe
Advertising
work@npg
Reprints and permissions
About this site
For librarians
 
NPG Resources
Nature
Nature Biotechnology
Nature Cell Biology
Nature Medicine
Nature Methods
Nature Reviews Cancer
Nature Reviews Genetics
Nature Reviews Molecular Cell Biology
news@nature.com
Nature Conferences
Nature Reports Stem Cells
RNAi Gateway
NPG Subject areas
Biotechnology
Cancer
Chemistry
Clinical Medicine
Dentistry
Development
Drug Discovery
Earth Sciences
Evolution & Ecology
Genetics
Immunology
Materials Science
Medical Research
Microbiology
Molecular Cell Biology
Neuroscience
Pharmacology
Physics
Browse all publications
Article
Nature Genetics  35, 148 - 157 (2003)
Published online: 14 September 2003; | doi:10.1038/ng1237

Transcriptome analysis of the acoelomate human parasite Schistosoma mansoni

Sergio Verjovski-Almeida1, Ricardo DeMarco1, Elizabeth A L Martins2, Pedro E M Guimarães3, Elida P B Ojopi3, Apuã C M Paquola4, João P Piazza5, Milton Y Nishiyama Jr.4, João P Kitajima5, 15, Rachel E Adamson6, Peter D Ashton6, Maria F Bonaldo7, Patricia S Coulson6, Gary P Dillon6, Leonardo P Farias2, Sheila P Gregorio1, 3, Paulo L Ho2, Ricardo A Leite8, L Cosme C Malaquias9, Regina C P Marques8, Patricia A Miyasato10, Ana L T O Nascimento2, Fernanda P Ohlweiler10, Eduardo M Reis1, 4, Marcela A Ribeiro11, Renata G Sá12, Gaëlle C Stukart3, M Bento Soares7, 13, Cybele Gargioni14, Toshie Kawano10, Vanderlei Rodrigues12, Alda M B N Madeira11, R Alan Wilson6, Carlos F M Menck8, João C Setubal5, Luciana C C Leite2 & Emmanuel Dias-Neto3

1  Departamento de Bioquimica, Instituto de Quimica, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil.

2  Centro de Biotecnologia, Instituto Butantan, 05503-900 São Paulo, SP, Brazil.

3  Laboratory of Neurosciences (LIM27), Instituto de Psiquiatria, HCFM, Universidade de São Paulo, 05403-010 São Paulo, SP, Brazil.

4  Laboratorio de Bioinformatica, Departmento de Bioquimica, Instituto de Quimica, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil.

5  Instituto de Computacao, C.P. 6176, Universidade Estadual de Campinas, 13084-971 Campinas, SP, Brazil.

6  Department of Biology, University of York, P.O. Box 373, York YO10 5YW, UK.

7  Department of Pediatrics, University of Iowa, Iowa City, Iowa 52242, USA.

8  Departamento de Microbiologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, Av. Prof. Lineu Prestes, 1374, 05508-900, São Paulo, SP, Brazil.

9  Universidade Vale do Rio Doce, 35030-390 Governador Valadares, MG, Brazil.

10  Laboratório de Parasitologia, Instituto Butantan, Av. Vital Brasil, 1500, 05503-900, São Paulo, SP, Brazil.

11  Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil.

12  Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes, 3900, 14049-900 Ribeirão Preto, SP, Brazil.

13  Departments of Biochemistry, Orthopaedics, Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA.

14  Departamento de Parasitologia, Instituto Adolfo Lutz, Av. Dr. Arnaldo n° 351, 8° andar, 01246-902 São Paulo, SP, Brazil.

15  Present address: Alellyx Applied Genomics, TechnoPark, rod. Anhanguera km 104, 13067-850 Campinas, SP, Brazil.

Correspondence should be addressed to Sergio Verjovski-Almeida verjo@iq.usp.br
Schistosoma mansoni is the primary causative agent of schistosomiasis, which affects 200 million individuals in 74 countries. We generated 163,000 expressed-sequence tags (ESTs) from normalized cDNA libraries from six selected developmental stages of the parasite, resulting in 31,000 assembled sequences and 92% sampling of an estimated 14,000 gene complement. By analyzing automated Gene Ontology assignments, we provide a detailed view of important S. mansoni biological systems, including characterization of metazoa-specific and eukarya-conserved genes. Phylogenetic analysis suggests an early divergence from other metazoa. The data set provides insights into the molecular mechanisms of tissue organization, development, signaling, sexual dimorphism, host interactions and immune evasion and identifies novel proteins to be investigated as vaccine candidates and potential drug targets.

MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated

REFERENCE
Parasitism: Life Cycles and Host Defences against Parasites
Nature Encyclopaedia of Life Sciences
Trematode Infections including Schistosomiasis
Nature Encyclopaedia of Life Sciences
 See all 5 matches for Reference

REVIEWS
The immunobiology of schistosomiasis
Nature Reviews Immunology Review Article (01 Jul 2002)

RESEARCH
Evolutionary and biomedical implications of a Schistosoma japonicum complementary DNA resource
Nature Genetics Article (01 Oct 2003)
Cost of resistance, expressed as a delayed maturity, detected in the host–parasite system Biomphalaria glabrata/Echinostoma caproni
Heredity Original Article (01 Mar 1998)
 See all 3 matches for Research

 Top
Abstract
Previous | Next
Table of contents
Full textFull text
Download PDFDownload PDF
Send to a friendSend to a friend
Save this linkSave this link

Open Innovation Challenges

naturejobs

Figures & Tables
Supplementary info
Export citation
natureproducts

Search buyers guide:

 
ADVERTISEMENT
 
Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
Journal home | Advance online publication | Current issue | Archive | Press releases | Supplements | Focuses | For authors | Online submission | Permissions | For referees | Free online issue | About the journal | Contact the journal | Subscribe | Advertising | work@npg | naturereprints | About this site | For librarians
Nature Publishing Group, publisher of Nature, and other science journals and reference works©2003 Nature Publishing Group | Privacy policy