Charlotte E. Remé and Andreas Wenzel are at the University Hospital Zürich, Laboratory of Retinal Cell Biology, Zürich, Switzerland. chreme@opht.unizh.ch & awenzel@opht.unizh.ch
The visual pigment rhodopsin consists of the apoprotein opsin and the retinoid chromophore 11-cis-retinal. Visual signaling is triggered upon photoisomerization of 11-cis-retinal into all-trans-retinal. A new study shows that visual signaling by opsin in the absence of chromophore is a pathogenetic mechanism of visual cell loss.
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