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The cyclin E–CDK2 complex was thought to be an essential regulator of the mitotic cell cycle. Surprisingly, disabling the critical genes in the mouse has fewer effects than anticipated.
Identification of a new imprinting control element (ICE) on mouse chromosome 12 brings the total to five. Common features of imprinting mechanisms suggest a general model of ICE function.
Huntington disease is caused by a polyglutamine repeat expansion in the huntingtin protein. A new study highlights an important role for the normal protein in neuronal transcriptional regulation.
The technical problem of detecting the retrotransposition—amplification and genomic dispersion of sequences through an RNA intermediate—of Pol III–directed transcripts has been solved. This provides a long-sought experimental system to learn how Alu repeats amplified to a high copy number in human DNA.
Answers to frequently asked questions about how to use genome sequence and annotation, written by leading researchers at the NHGRI to provide an introduction and guide for all genetics and bioinformatics researchers.
