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Review
Nature Genetics  34, 369 - 376 (2003)
Published online: 30 July 2003; | doi:10.1038/ng1215

Chromosome aberrations in solid tumors

Donna G Albertson1, 2, Colin Collins1, 2, Frank McCormick1, 3 & Joe W Gray2, 4

1  Cancer Research Institute, University of California San Francisco, San Francisco, California 94143-0808, USA.

2  Department of Laboratory Medicine, University of California San Francisco, San Francisco, California 94143-0808, USA.

3  Department of Microbiology and Immunology, University of California San Francisco, San Francisco, California 94143-0808, USA.

4  Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA.

Correspondence should be addressed to Donna G Albertson albertson@cc.ucsf.edu or Joe W Gray jwgray@lbl.gov
Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability. This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms by which aberrations may form during cancer progression and provides examples of clinical advances that have come from studies of chromosome aberrations.

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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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