Nature Genetics
34, 377 - 378 (2003)
Published online: 6 July 2003; | doi:10.1038/ng1209
Essentiality, not expressiveness, drives gene-strand bias in bacteriaEduardo P C Rocha1, 2
& Antoine Danchin1, 31
Unité GGB, URA 2171, Institut Pasteur, 28 rue Dr. Roux, 75015 Paris, France. 2
Atelier de BioInformatique, Université Pierre et Marie Curie, 12 rue Cuvier, 75005 Paris, France. 3
HKU-Pasteur Research Centre, Dexter HC Man Building, 8, Sassoon Road, Pokfulam, Hong Kong.
Correspondence should be addressed to Eduardo P C Rocha erocha@pasteur.frPreferential positioning of bacterial genes in the leading strand was thought to result from selection to avoid high head-on collision rates between DNA and RNA polymerases. Here we show, however, that in Bacillus subtilis and Escherichia coli, essentiality (the transcript product), not expressiveness (the collision rate), selectively drives the biased gene distribution.
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29 DNA polymerase is dependent on RNA polymerase translocation
29 DNA replication arrest caused by codirectional collisions with the transcription machinery
