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News and Views
Nature Genetics  34, 357 - 358 (2003)
doi:10.1038/ng0803-357


There is an Erratum (September 2003) associated with this News and Views.

A new piece of the ALS puzzle

John L Cleveland

John L. Cleveland is in the Department of Biochemistry at St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. john.cleveland@stjude.org

The molecular pathogenesis of most forms of amyotrophic lateral sclerosis (ALS) is poorly understood. Now, reduced expression of vascular endothelial growth factor (VEGF) is shown to be a risk factor for contracting ALS. Addition of Vegf in mice is shown to protect motoneurons from damage.

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RESEARCH
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
Nature Genetics Article (01 Aug 2003)

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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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