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Letter

Nature Genetics 34, 287–291 (1 July 2003) | doi:10.1038/ng1177

Spatial proximity of translocation-prone gene loci in human lymphomas

Jeffrey J Roix , Philip G McQueen , Peter J Munson , Luis A Parada & Tom Misteli

Cancer cells frequently have disease-specific chromosome rearrangements. It is poorly understood why translocations between chromosomes recur at specific breakpoints in the genome.