Nature Genetics34, 264 - 266 (2003)
Published online: 22 June 2003; | doi:10.1038/ng1181
Convergent evolution of gene circuits
Gavin C Conant
& Andreas Wagner
Department of Biology, 167 Castetter Hall, The University of New Mexico, Albuquerque, New Mexico 87131, USA.
Correspondence should be addressed to Andreas Wagner wagnera@unm.edu
Convergent evolution is a potent indicator of optimal design. We show here that convergent evolution occurs in genetic networks. Specifically, we show that multiple types of transcriptional regulation circuitry in Escherichia coli and the yeast Saccharomyces cerevisiae have evolved independently and not by duplication of one or a few ancestral circuits.
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