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News and Views
Nature Genetics  34, 244 - 245 (2003)
doi:10.1038/ng0703-244

PGC-1alpha at the crossroads of type 2 diabetes

Alan D Attie & Christina M Kendziorski

A.D.A. is in the Department of Biochemistry and C.M.K. is in the Department of Biostatistics and Medical Informatics at the University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. attie@biochem.wisc.edu or kendzior@biostat.wisc.edu

Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein-bold gamma co-activator-1alpha (PGC-1alpha) seems to be in charge of this orchestrated change in gene expression.

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