The author is in the Department of Medicine, University of Washington, Seattle, Washington 98195, USA. drussell@u.washington.edu
Adeno-associated virus (AAV) holds much promise as a vector for gene therapy. Although transgene expression usually occurs from extrachromosomal vector genomes, vectors occasionally integrate into the host genome. A new study in normal mammalian cells shows that the insertions are associated with genomic deletions and occur preferentially in actively transcribed genes.
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