1
C.T.M. is in the Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. mcmurray.cynthia@mayo.edu
2
J.A.T. is in the Department of Molecular Biology and Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, California 92037, USA and in the Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. jat@scripps.edu
The direct inhibition of DNA mismatch repair by cadmium provides a molecular mechanism for cadmium toxicity with profound implications for human health, risk assessment and biological understanding of environmental mutagens. Alteration of key DNA damage response pathways may prove even more important than direct DNA damage by mutagens.
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