The authors are in the Laboratory of Mammalian Genes and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
In a new study, the presence of a CpG island transgene protects neighboring sequence from DNA methylation during development leading to an open chromatin state that persists in the adult animal. This study suggests the importance of DNA methylation in setting up the epigenome.
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