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Letter

Nature Genetics 34, 102–107 (1 May 2003) | doi:10.1038/ng1152

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis

Martina Muckenthaler , Cindy N. Roy , |[Aacute]|ngel O. Custodio , Bel|[eacute]|n Mi|[ntilde]|ana , Jos deGraaf , Lynne K. Montross , Nancy C. Andrews & Matthias W. Hentze

Individuals with hereditary hemochromatosis suffer from systemic iron overload due to duodenal hyperabsorption. Most cases arise from a founder mutation in HFE (845G|[rarr]|A; ref.