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Letter
Nature Genetics 34, 85–90 (1 May 2003) | doi:10.1038/ng1151
Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells
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Abstract
To elucidate the genomics of cellular responses to cancer treatment, we analyzed the expression of over 9,600 human genes in acute lymphoblastic leukemia cells before and after in vivo treatment with methotrexate and mercaptopurine given alone or in combination. Based on changes in gene expression, we identified 124 genes that accurately discriminated among the four treatments.
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