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Letter

Nature Genetics 34, 108–112 (1 May 2003) | doi:10.1038/ng1148

Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia

Pamela M. Pollock , Karine Cohen-Solal , Raman Sood , Jin Namkoong , Jeffrey J. Martino , Aruna Koganti , Hua Zhu , Christiane Robbins , Izabela Makalowska , Seung-Shick Shin , Yari Marin , Kathleen G. Roberts , Laura M. Yudt , Amy Chen , Jun Cheng , Arturo Incao , Heather W. Pinkett , Christopher L Graham , Karen Dunn , Steven M. Crespo-Carbone , Kerine R. Mackason , Kevin B. Ryan , Daniel Sinsimer , James Goydos , Kenneth R. Reuhl , Michael Eckhaus , Paul S. Meltzer , William J. Pavan , Jeffrey M. Trent & Suzie Chen

To gain insight into melanoma pathogenesis, we characterized an insertional mouse mutant, TG3, that is predisposed to develop multiple melanomas. Physical mapping identified multiple tandem insertions of the transgene into intron 3 of Grm1 (encoding metabotropic glutamate receptor 1) with concomitant deletion of 70 kb of intronic sequence.