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Brief Communication

Nature Genetics 34, 32–33 (1 May 2003) | doi:10.1038/ng1141

Dax1 is required for testis determination

Joshua J. Meeks , Jeffrey Weiss & J. Larry Jameson

The orphan nuclear receptor, Dax1, was originally proposed to act as an 'anti-testis' factor. We find, however, that Nr0b1 (also called Dax1 and Ahch, which encodes Dax1) is in fact required for testis differentiation.