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Letter
Nature Genetics 33, 522–526 (1 April 2003) | doi:10.1038/ng1132
Sir3p phosphorylation by the Slt2p pathway effects redistribution of silencing function and shortened lifespan
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Abstract
An organism's lifespan is modulated by environmental conditions. When nutrients are abundant, the metabolism of many organisms shifts to growth or reproduction at the expense of longer lifespan, whereas a scarcity of nutrients reverses this shift.
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