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Review
Nature Genetics  33, 305 - 310 (2003)
doi:10.1038/ng1109

Bioinformatics in the post-sequence era

Minoru Kanehisa1 & Peer Bork2

1  Bioinformatics Center, Kyoto University, Uji, Kyoto 611-0011, Japan.

2  European Molecular Biology Laboratory, 69012 Heidelberg, Germany.

Correspondence should be addressed to Minoru Kanehisa kanehisa@kuicr.kyoto-u.ac.jp
In the past decade, bioinformatics has become an integral part of research and development in the biomedical sciences. Bioinformatics now has an essential role both in deciphering genomic, transcriptomic and proteomic data generated by high-throughput experimental technologies and in organizing information gathered from traditional biology. Sequence-based methods of analyzing individual genes or proteins have been elaborated and expanded, and methods have been developed for analyzing large numbers of genes or proteins simultaneously, such as in the identification of clusters of related genes and networks of interacting proteins. With the complete genome sequences for an increasing number of organisms at hand, bioinformatics is beginning to provide both conceptual bases and practical methods for detecting systemic functional behaviors of the cell and the organism.

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Nature Genetics
ISSN: 1061-4036
EISSN: 1546-1718
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