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Review
Nature Genetics  33, 311 - 323 (2003)
doi:10.1038/ng1106

Proteomics: the first decade and beyond

Scott D. Patterson1, 3 & Ruedi H. Aebersold2

1  Celera Genomics Corporation, 45 West Gude Drive, Rockville, Maryland 20850, USA.

2  Institute for Systems Biology, 1441 North 34th Street, Seattle, Washington 98103, USA.

3  Present address: Farmal Biomedicines, LLC, 129 North Hill Avenue, Suite #107, Pasadena, California 91106, USA.

Correspondence should be addressed to Scott D. Patterson scottp@farmalbiomed.com
Proteomics is the systematic study of the many and diverse properties of proteins in a parallel manner with the aim of providing detailed descriptions of the structure, function and control of biological systems in health and disease. Advances in methods and technologies have catalyzed an expansion of the scope of biological studies from the reductionist biochemical analysis of single proteins to proteome-wide measurements. Proteomics and other complementary analysis methods are essential components of the emerging 'systems biology' approach that seeks to comprehensively describe biological systems through integration of diverse types of data and, in the future, to ultimately allow computational simulations of complex biological systems.

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