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Letter

Nature Genetics 33, 382–387 (1 March 2003) | doi:10.1038/ng1100

Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots

M.S. Phillips , R. Lawrence , R. Sachidanandam , A.P. Morris , D.J. Balding , M.A. Donaldson , J.F. Studebaker , W.M. Ankener , S.V. Alfisi , F.-S. Kuo , A.L. Camisa , V. Pazorov , K.E. Scott , B.J. Carey , J. Faith , G. Katari , H.A. Bhatti , J.M. Cyr , V. Derohannessian , C. Elosua , A.M. Forman , N.M. Grecco , C.R. Hock , J.M. Kuebler , J.A. Lathrop , M.A. Mockler , E.P. Nachtman , S.L. Restine , S.A. Varde , M.J. Hozza , C.A. Gelfand , J. Broxholme , G.R. Abecasis , M.T. Boyce-Jacino & L.R. Cardon

Recent studies of human populations suggest that the genome consists of chromosome segments that are ancestrally conserved ('haplotype blocks'; refs. 1–3) and have discrete boundaries defined by recombination hot spots.